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Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women
Author(s) -
Cornette J,
Duvekot JJ,
RoosHesselink JW,
Hop WCJ,
Steegers EAP
Publication year - 2011
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2010.02794.x
Subject(s) - nifedipine , medicine , hemodynamics , afterload , fetus , blood pressure , pregnancy , obstetrics , anesthesia , cardiology , biology , genetics , calcium
Please cite this paper as: Cornette J, Duvekot J, Roos‐Hesselink J, Hop W, Steegers E. Maternal and fetal haemodynamic effects of nifedipine in normotensive pregnant women. BJOG 2011;118:510–515. While nifedipine is commonly used for tocolysis, the controversy on its safety remains. So far, the haemodynamic effects on maternal and fetal circulations have not been well documented. Fifteen normotensive women who received 20 mg nifedipine were included in this prospective observational study. The maternal and fetal haemodynamic effects were analysed using maternal echocardiography and fetal Doppler ultrasonography. Nifedipine induced a significant afterload reduction in all women. It triggered a compensatory increase in cardiac output, which maintained blood pressure. These maternal changes had no influence on the uteroplacental and fetal circulations.