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Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease
Author(s) -
Schmidt KT,
Larsen EC,
Andersen CY,
Andersen AN
Publication year - 2010
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2009.02408.x
Subject(s) - fertility , fertility preservation , medicine , radiation therapy , disease , ovarian tissue , ovarian tissue cryopreservation , gynecology , infertility , premature ovarian failure , pediatrics , ovary , pregnancy , environmental health , biology , population , genetics
Please cite this paper as: Schmidt K, Larsen E, Andersen C, Andersen A. Risk of ovarian failure and fertility preserving methods in girls and adolescents with a malignant disease. BJOG 2010;117:163–174. Girls and young women suffering from a malignant disease that requires treatment with chemo‐ and/or radiotherapy are at risk of losing fertility. The most significant risk factors are age and type of treatment given. Preserving fertility is of high priority to both the young patient and her parents. This article reviews the effect of chemo‐ and radiotherapy on gonadal function, and thus fertility, and offers different fertility preserving methods based on the literature. Cryopreservation of ovarian tissue is a possible way of preserving fertility in this group of patients in the future.