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Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry
Author(s) -
Huissoud C,
Carrabin N,
Audibert F,
Levrat A,
Massig D,
Berland M,
Rudigoz RC
Publication year - 2009
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2009.02187.x
Subject(s) - fibrinogen , postpartum haemorrhage , medicine , population , pregnancy , obstetrics , gynecology , anesthesia , genetics , biology , environmental health
Objectives To establish whether reagent‐supported thrombelastometry with the rotation thrombelastometry system (ROTEM ® ) point‐of‐care device correlated with fibrinogen level in postpartum haemorrhages. Design Prospective observational study. Population and setting Ninety‐one women at the third trimester of pregnancy: 37 with postpartum haemorrhage (study group) and 54 without abnormal bleeding (control group). Methods Standard laboratory test results were compared with those obtained at bedside from the ROTEM with the FIBTEM ® test (54 tests in the control group and 51 in the study group). Main outcome measures Analysis of correlations between fibrinogen levels and FIBTEM test results: clotting time (CT), clot amplitude at 5 and 15 minutes (CA 5 ; CA 15 ) and maximal amplitude [maximum clot firmness (MCF)]. Results Median fibrinogen level was significantly lower in the haemorrhage group than in the control group (3.4 and 5.1 g/l, respectively, P < 0.0001). Median CT was higher in the haemorrhage group than in the control group ( P = 0.05). CA 5 , CA 15 and MCF were significantly lower in the haemorrhage group than in controls ( P < 0.0001) and strongly correlated with fibrinogen levels in both groups ( r = 0.84–0.87, P < 0.0001). A cut‐off value of CA 5 at 5 mm and CA 15 at 6 mm presented an excellent sensitivity (100% for both parameters) and a good specificity (respectively 85 and 88%) to detect fibrinogen levels <1.5 g/l in postpartum haemorrhage. Conclusions The early parameters obtained from the FIBTEM test correlated well with fibrinogen levels. ROTEM might be helpful in guiding fibrinogen transfusion during postpartum haemorrhage.