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First trimester urinary placental growth factor and development of pre‐eclampsia
Author(s) -
Savvidou MD,
Akolekar R,
Zaragoza E,
Poon LC,
Nicolaides KH
Publication year - 2009
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2008.02074.x
Subject(s) - placental growth factor , medicine , eclampsia , interquartile range , creatinine , urinary system , gestation , gestational age , pregnancy , obstetrics , gynecology , urology , biology , vascular endothelial growth factor , vegf receptors , genetics
Objective To compare urinary placental growth factor (PlGF) concentration at 11 +0 to 13 +6 weeks of gestation in women who subsequently develop pre‐eclampsia with normotensive controls. Design Nested case–control study within a prospective study for first trimester prediction of pre‐eclampsia. Setting Routine antenatal visit in a teaching hospital. Population Fifty‐two women who developed pre‐eclampsia and 52 controls matched for gestational age and sample storage time. Methods Urinary PlGF concentration and PlGF to creatinine ratio were measured in women who developed pre‐eclampsia and their matched controls. Comparisons between groups were performed using Student’s t test. Main outcome measures Development of pre‐eclampsia. Results In the pre‐eclampsia group, the median urinary PlGF concentration (20.6 pg/ml, interquartile range [IQR] 9.1–32.0 pg/ml) and median urinary PlGF to creatinine ratio (1.6 pg/mg, IQR 1.2–2.5 pg/mg) were not significantly different from the control group (11.8 pg/ml, IQR 5.5–29.8 pg/ml, P = 0.1 and 1.7 pg/mg, IQR 1.2–2.3 pg/mg, P = 0.3, respectively). There were no significant differences between women with early‐onset pre‐eclampsia requiring delivery before 34 weeks ( n = 13) and those with late‐onset pre‐eclampsia ( n = 39) and between women with pre‐eclampsia and fetal growth restriction (FGR) ( n = 25) and those with pre‐eclampsia and no FGR ( n = 27) in either median PlGF concentration or median urinary PlGF to creatinine ratio. Conclusions The development of pre‐eclampsia is not preceded by altered urinary PlGF concentration in the first trimester of pregnancy.