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Neonatal alloimmune thrombocytopenia in Norway: poor detection rate with nonscreening versus a general screening programme
Author(s) -
Tiller H,
Killie MK,
Skogen B,
Øian P,
Husebekk A
Publication year - 2009
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2008.02068.x
Subject(s) - neonatal alloimmune thrombocytopenia , medicine , population , obstetrics , pregnancy , fetus , biology , environmental health , genetics
The implementation of an antenatal screening programme for neonatal alloimmune thrombocytopenia (NAIT) is currently under debate. We evaluated the detection rate for NAIT in a nonscreened population of 661 200 births where NAIT was diagnosed on clinical indication. We did a cross‐sectional comparison with a population of 100 448 human platelet antigen 1a (HPA1a)‐screened pregnancies from three of the five health regions in Norway. In a nonscreening situation, 7.5 cases of NAIT were detected per year compared with 53 cases when screening was applied. The detection rate of NAIT in Norway was therefore 14% of the expected rate.