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Use of povidone–iodine during the first trimester of pregnancy: a correct practice?
Author(s) -
Velasco I,
Naranjo S,
LópezPedrera C,
Garriga MJ,
GarcíaFuentes E,
Soriguer F
Publication year - 2009
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2008.02059.x
Subject(s) - miscarriage , iodine , pregnancy , antiseptic , medicine , thyroid function , thyroid , excretion , hormone , urinary system , fetus , physiology , thyroid function tests , obstetrics , gynecology , endocrinology , chemistry , biology , pathology , genetics , organic chemistry
Povidone–iodine (PVP‐I) has been widely used as an antiseptic agent during invasive procedures for prenatal diagnosis. Women have been reported of thyroid dysfunction after simple exposure to PVP‐I. We studied the effect on thyroid function and urinary iodine excretion after a single topical application of PVP‐I in 31 women who had a miscarriage during the first trimester of pregnancy. PVP‐I is absorbed through the skin and the vaginal mucosa, resulting in a sudden increase in the urinary excretion of iodine and a short‐term variation in concentrations of thyroid hormones in maternal serum. This metabolic effect could have consequences for the embryo and the fetus during crucial stages of development.