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Fetal mesenchymal stem cells: isolation, properties and potential use in perinatology and regenerative medicine
Author(s) -
Gucciardo L,
Lories R,
OchsenbeinKölble N,
Done’ E,
Zwijsen A,
Deprest J
Publication year - 2009
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2008.02005.x
Subject(s) - regenerative medicine , fetus , mesenchymal stem cell , placenta , stem cell , tissue engineering , amniotic stem cells , fetal membrane , embryonic stem cell , amniotic fluid , medicine , andrology , microbiology and biotechnology , biology , pathology , adult stem cell , pregnancy , biomedical engineering , genetics , gene
The fetus is a source of nonembryonic stem cells (SC), with potential applications in perinatal medicine. Cells derived from the placenta, membranes, amniotic fluid or fetal tissues are higher in number, expansion potential and differentiation abilities compared with SC from adult tissues. Although some obstacles keep SC biology at distance from clinical application, the feasibility of using (homologous) SC for tissue engineering for the fetus with a congenital birth defect has been demonstrated. Also, other pathologies may benefit from SC technology.