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An introduction to Toll‐like receptors and their possible role in the initiation of labour
Author(s) -
Patni S,
Flynn P,
Wynen LP,
Seager AL,
Morgan G,
White JO,
Thornton CA
Publication year - 2007
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2007.01488.x
Subject(s) - toll , receptor , inflammation , toll like receptor , pathological , biology , preterm labor , tlr4 , pregnancy , preterm labour , immunology , gestation , microbiology and biotechnology , innate immune system , medicine , genetics
Toll‐like receptors (TLR) have emerged as key upstream mediators of inflammation at many tissue sites in humans. Inflammatory processes are involved in the process of parturition suggesting that TLR activity within gestation‐associated tissues might have an important role in the initiation and/or maintenance of normal term labour and in various pathological states of pregnancy such as infection‐associated preterm labour. Either TLRs or their signalling molecules might be excellent therapeutic targets for prevention of preterm labour.