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Differences in current clinical features of diploid and triploid hydatidiform mole
Author(s) -
Niemann I,
Petersen LK,
Hansen ES,
Sunde L
Publication year - 2007
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2007.01449.x
Subject(s) - molar pregnancy , ploidy , mole , molar , pregnancy , logistic regression , obstetrics , retrospective cohort study , gynecology , products of conception , biology , medicine , gestation , genetics , gene , paleontology
Objective To describe and compare the current clinical features of diploid and triploid molar pregnancy and to evaluate whether the presenting clinical features can predict the ploidy of a molar pregnancy. Design A retrospective study of the clinical features and ploidy of hydatidiform moles. Setting The Departments of Clinical Genetics and Pathology, Aarhus University Hospital and 13 gynaecological wards, Jutland, Denmark. Population A total of 259 women with molar pregnancy diagnosed between April 1986 and June 2003. Methods A review of medical records of consecutively collected, clinically suspected cases of molar pregnancy was performed. The molar ploidy was determined by karyotyping, flow cytometry, and/or analysis of polymorphic DNA markers. Main outcome measures Maternal characteristics, presenting symptoms, initial human chorionic gonadotrophin (hCG), and molar ploidy. Results In a multiple logistic regression model, initial hCG of ≥100 000 iu/l ( P < 0.001), first‐trimester gestational age ( P < 0.001), vaginal bleeding ( P < 0.001), and maternal age of ≥40 years ( P = 0.03) were independent predictors of diploid mole. Women with excessive uterine size more frequently had a diploid than a triploid mole ( P < 0.001). Fifty‐four percent of the women with triploid mole and 27% of the women with diploid mole were diagnosed before onset of symptoms ( P < 0.001). Conclusions The current clinical features of diploid mole are different from those of triploid mole. The presenting clinical profile of a molar pregnancy may be used as an early predictor of the molar ploidy and thus of the prognosis.