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Local inflammatory response in choriodecidua induced by Ureaplasma urealyticum
Author(s) -
Aaltonen R,
Heikkinen J,
Vahlberg T,
Jensen JS,
Alanen A
Publication year - 2007
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2007.01410.x
Subject(s) - ureaplasma urealyticum , lipopolysaccharide , secretion , microbiology and biotechnology , amniotic fluid , mycoplasmataceae , inflammatory response , tumor necrosis factor alpha , stimulation , bacteria , cytokine , prostaglandin e2 , interleukin 6 , biology , immunology , inflammation , mycoplasma , endocrinology , pregnancy , mollicutes , fetus , genetics
Ureaplasma urealyticum is the bacterial species most often connected with preterm birth, although it often colonises the amniotic fluid without any adverse effects. The induction of preterm labour seems to depend on whether the bacteria produce an inflammatory reaction. In vitro stimulation of choriodecidual tissue with high amounts of U. urealyticum or with lipopolysaccharide induced a qualitatively similar inflammatory response detected by the production of tumour necrosis factor alpha, followed by secretion of anti‐inflammatory cytokine interleukin‐10 and of prostaglandin E 2 . Lower quantities of bacteria failed to induce any response.