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Practical issues drawn from the implementation of the integrated test for Down syndrome screening into routine clinical practice
Author(s) -
Weisz B,
Pandya P,
Chitty L,
Jones P,
Huttly W,
Rodeck C
Publication year - 2007
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2007.01238.x
Subject(s) - test (biology) , medical physics , computer science , clinical practice , medicine , family medicine , biology , paleontology
We have evaluated a cohort of women booked for antenatal care at University College London Hospitals. The uptake of screening was 64.4% and was significantly higher (73 versus 46%) in women who booked before 14 weeks. Of the women who booked before 14 weeks, 96.8% opted for the integrated test (IT). Overall, 5.3% failed to attend for the second blood test. The false‐positive rate in the women who had the IT was 2.9%. All 11 cases of Down syndrome were detected prenatally. Our study is the first to evaluate implementation of the IT into routine clinical practice.