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Intravenous anti‐D immunoglobulin in the treatment of resistant immune thrombocytopenic purpura in pregnancy
Author(s) -
Sieunarine K,
Shapiro S,
Al Obaidi MJ,
Girling J
Publication year - 2007
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2007.01234.x
Subject(s) - medicine , thrombocytopenic purpura , pregnancy , platelet , prednisolone , antibody , immune system , purpura (gastropod) , immunology , gastroenterology , immune thrombocytopenia , biology , ecology , genetics
A 35‐week pregnant 38‐year‐old woman presented with isolated thrombocytopenia (platelet count 4 × 10 9 /l). Investigations confirmed immune thrombocytopenic purpura, and she received treatment with prednisolone and intravenous immunoglobulins with no increment in the platelet count. At 37 and 38 weeks of the pregnancy, she received two doses of WinRho (anti‐D immunoglobulin) at 50 μg/kg. Five days later, with a platelet count of 46 × 10 9 /l, she had an uncomplicated normal vaginal delivery. WinRho is a useful adjunct to other first‐line treatment modalities for immune thrombocytopenia in pregnancy.