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Glycaemic control throughout pregnancy and risk of pre‐eclampsia in women with type I diabetes
Author(s) -
Temple RC,
Aldridge V,
Stanley K,
Murphy HR
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2006.01071.x
Subject(s) - medicine , eclampsia , pregnancy , obstetrics , diabetes mellitus , prospective cohort study , type 2 diabetes , cohort study , case control study , gynecology , endocrinology , genetics , biology
The aim of this study was to examine the influence of pre‐pregnancy care and its effect on early glycaemic control and also the effect of glycaemic control in later pregnancy on risk of pre‐eclampsia in women with type I diabetes. A prospective cohort study of 290 consecutive nonselected pregnancies in women with type I diabetes was performed from 1991 to 2002. We examined the relationship of monthly glycosylated haemoglobin (HbA1c) level, pre‐pregnancy care, parity, diabetes duration, microvascular complications, maternal age, weight and smoking with risk of pre‐eclampsia. Pre‐eclampsia developed in 31/243 singleton births (12.8%). HbA1c level at 24 weeks was significantly increased in women with pre‐eclampsia compared with women without pre‐eclampsia (6.0 versus 5.6%, P = 0.017) and was, after nulliparity, the strongest independent predictor of increased risk (OR 1.65 for each 1% increase in HbA1c; P = 0.01). In contrast, there was no relationship between pre‐pregnancy care or HbA1c level at booking and risk of pre‐eclampsia.