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Compliance with routine antenatal rhesus D prophylaxis and the impact on sensitisations: observations over 14 years
Author(s) -
MacKenzie IZ,
Findlay J,
Thompson K,
Roseman F
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2006.00988.x
Subject(s) - medicine , obstetrics , gestation , pregnancy , pediatrics , biology , genetics
Documented routine antenatal anti‐D prophylaxis was given to 90% and 81–87% of eligible women at 28 and 34 weeks of gestation, respectively, during the early 1990s and early 2000s. With increasing experience and education, a significant improvement in the timing of the first (OR 0.26, 95% CI 0.16–0.41: P < 0.0001) and second injections (OR 0.40, 95% CI 0.26–0.61: P < 0.0001) occurred during the latter period. Despite these improvements, there was no reduction in the sensitisation rate at 0.4%. However, this low rate occurred despite significant proportions of women delivering more than 42 days after the second injection. Fifteen of the 16 sensitised women had received routine antenatal prophylaxis.