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The IL‐10 −1082G polymorphism is associated with clearance of HPV infection
Author(s) -
Farzaneh F,
Roberts SA,
Mandal D,
Ollier B,
Winters U,
Kitchener HC,
Brabin L
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2006.00956.x
Subject(s) - genotype , cervical cancer , allele , cervical intraepithelial neoplasia , medicine , hpv infection , human papillomavirus , allele frequency , polymorphism (computer science) , gynecology , gastroenterology , biology , cancer , gene , genetics
The role of cytokines in protecting against human papillomavirus (HPV) and HPV‐associated disease is not fully understood. We compared the frequency of the interleukin (IL)‐10 polymorphism (G allele) at position −1082 and the distribution of GG/GA/AA genotypes among 116 HPV‐positive women, grouped according to their cervical cytological profiles, with 119 HPV‐negative controls with normal smears. No difference was observed in genotype frequency between the groups. Among women in the HPV‐positive, smear‐normal group, who were re‐tested for HPV after 12 months, there was a significant inverse association between presence of at least one variant G allele (high activity) and HPV persistence (OR per G allele = 0.082 [95% CI 0.009–0.73], P = 0.001; after controlling for ethnicity). This association remained significant after controlling for age, smoking and hormonal contraception (OR = 0.028 [95% CI 0.001–0.66], P = 0.001). This preliminary study suggests that higher levels of IL‐10 may prevent cervical neoplasia through their role in eliminating HPV.