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Short communication: Association of pre‐eclampsia with the R563Q mutation of the β‐subunit of the epithelial sodium channel
Author(s) -
Dhanjal MK,
Owen EP,
Anthony JA,
Davidson JS,
Rayner BL
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2006.00899.x
Subject(s) - association (psychology) , eclampsia , sodium channel , protein subunit , mutation , channel (broadcasting) , epithelial sodium channel , genetics , sodium , chemistry , biology , medicine , psychology , pregnancy , computer science , computer network , gene , organic chemistry , psychotherapist
The R563Q mutation of the β‐subunit of the epithelial sodium channel (ENaC) is associated with hypertension in black and mixed ancestry (MA) men and women in South Africa. The frequency of the R563Q mutation in black and MA women with pre‐eclampsia ( n = 230) and in controls ( n = 198) was studied. The R563Q mutation was found in 7.8% of the women with pre‐eclampsia and in 2.6% of controls ( P = 0.014). This remained significant if the black women were analysed separately ( P = 0.031). We have demonstrated that a genetic variant of the ENaC is associated with pre‐eclampsia. This has implications for understanding the pathogenesis and treatment of pre‐eclampsia.