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Non‐invasive first trimester determination of fetal gender: a new approach for prenatal diagnosis of haemophilia
Author(s) -
Chi C,
Hyett JA,
Finning KM,
Lee CA,
Kadir RA
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2006.00813.x
Subject(s) - fetus , medicine , obstetrics , prenatal diagnosis , haemophilia , gestation , pregnancy , cell free fetal dna , haemophilia a , gynecology , pediatrics , biology , genetics
Ten carriers of haemophilia referred for prenatal diagnosis were offered first trimester non‐invasive fetal gender determination by ultrasound and analysis of free fetal DNA (ffDNA) in maternal plasma in an attempt to reduce the need for an invasive diagnostic procedure in female pregnancies. Although repeat testing was required in three cases, fetal gender was determined correctly in all cases (four females, six males) at a median gestation of 12 +3 (11 +2 to 14 +1 ) using both methods. In all cases of a female fetus, the mothers opted not to have invasive testing. Both methods provide a reliable option of avoiding invasive testing in female pregnancies.