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Angiotensinogen gene variants and small‐for‐gestational‐age infants
Author(s) -
Tower C,
Chappell S,
Kalsheker N,
Baker P,
Morgan L
Publication year - 2006
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2005.00841.x
Subject(s) - small for gestational age , body mass index , haplotype , obstetrics , gestational age , genotype , fetus , blood pressure , mass index , medicine , gestation , pregnancy , endocrinology , gene , biology , genetics
In 2003, the angiotensinogen ( AGT ) gene was found to be associated with infants small for gestational age (SGA). The present study of 107 pregnancies affected by SGA infants and 101 normal pregnancies was designed to further investigate this association. Maternal or fetal AGT genotype or haplotype frequencies did not differ between SGA and normal pregnancies ( P > 0.35). Quantitative trait analysis of mothers with normal pregnancies demonstrated an association between AGT haplotype and blood pressure and body mass index at antenatal booking ( P = 0.04), suggesting that AGT may play a role in the complex relationship between body mass and blood pressure in healthy pregnant women.