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The effect of prepartum antibiotics on the type of neonatal bacteraemia: insights from the MRC ORACLE trials
Author(s) -
Gilbert R.E.,
Pike K.,
Kenyon S.L.,
TarnowMordi W.,
Taylor D.J.
Publication year - 2005
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2005.00558.x
Subject(s) - medicine , antibiotics , rupture of membranes , group b , neonatal sepsis , pediatrics , relative risk , obstetrics , randomized controlled trial , pregnancy , sepsis , microbiology and biotechnology , gestation , biology , confidence interval , genetics
We analysed the type of bacteraemia before discharge from Neonatal Intensive Care Units in babies born to women randomised to the MRC ORACLE Trials. There was no evidence for an effect of oral antibiotics given prior to delivery on bacteraemia due to gram negative or enterococci bacteria, but Group B streptococcal (GBS) bacteraemia was significantly reduced in women with preterm prelabour rupture of the membranes (1.58% to 0.55%, relative risk 0.34; 95% CI: 0.17–0.70). There was no detectable effect in women in spontaneous preterm labour with intact membranes as the risk of GBS bacteraemia in their babies was very small regardless of treatment.