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Does regular cervical screening protect women from microinvasive squamous cell carcinoma of the cervix? A retrospective case–control study
Author(s) -
Sykes Peter H.,
Reddy Jessamine,
Peddie David J.
Publication year - 2005
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2005.00537.x
Subject(s) - medicine , cervix , cervical intraepithelial neoplasia , gynecology , cervical screening , retrospective cohort study , obstetrics , basal cell , confidence interval , cervical cancer , surgery , cancer
Objectives To compare the smear histories of women with microinvasive squamous cell carcinoma (SCC) of the cervix to those of women with cervical intraepithelial neoplasia grade 3 (CIN3). Design Retrospective case–control study. Setting A large public hospital gynaecology unit. Sample Twenty‐nine consecutive women with microinvasive SCC FIGO stage 1A1 (cases). Fifty‐five age‐matched controls with histologically confirmed CIN3 (controls). Methods The cases and controls were selected from institutional databases; smear histories and other information was retrieved from hospital notes or following consent from other records. Main outcome measures The time from index smear to prior screening smear and participation in the National Screening Programme (NCSP). Results Only 35% of cases compared with 78% controls had a smear in the last 3 years ( P = 0.00008.) Cases had a longer median interval between the abnormal smear that resulted in diagnosis and the previous screening smear (4 years) compared with controls (2 years). Cases were less likely to be enrolled in the NCSP (65%) prior to their index smear than controls (85%). Conclusion Delayed interval screening was more frequent in women with 1A1 SCC than CIN3.