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Antioxidants and preterm prelabour rupture of the membranes
Author(s) -
Mathews Fiona,
Neil Andrew
Publication year - 2005
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2005.00500.x
Subject(s) - medicine , pregnancy , lutein , obstetrics , rupture of membranes , prospective cohort study , population , cohort study , gynecology , gestational age , environmental health , carotenoid , food science , biology , genetics
Objective To investigate the relationships of dietary intakes and serum levels of antioxidant nutrients to the risk of prelabour rupture of the membranes preterm (PPROM). Design A prospective observational cohort study. Setting A district general hospital in the south of England. Population Eight hundred and twelve white nulliparous women with singleton pregnancies. Methods Serum antioxidant concentrations and dietary intakes were measured in the second trimester. Associations with the risk of PPROM were investigated. Main outcome measure Preterm prelabour rupture of the membranes. Result Serum concentrations of the antioxidant lutein, but no other nutrient, was associated with the risk of PPROM. Maternal smoke exposure (serum cotinine) also predicted PPROM. Women with high serum lutein concentrations (top third) in early pregnancy had four times greater risk than women in the lowest third (95% CI 1.3–11.9; P = 0.009) after adjusting for smoke exposure. Similar results were obtained using lutein levels from later pregnancy. Conclusion We found no evidence that antioxidant nutrients are protective against PPROM. Rather, high levels of lutein were associated with an increased risk.