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Bed rest versus free mobilisation following embryo transfer: a prospective randomised study
Author(s) -
Amarin Zouhair O.,
Obeidat Basil R.
Publication year - 2004
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2004.00346.x
Subject(s) - embryo transfer , medicine , bed rest , pregnancy , controlled ovarian hyperstimulation , gestation , pregnancy rate , in vitro fertilisation , gynecology , live birth , prospective cohort study , randomized controlled trial , obstetrics , fertilisation , reproductive technology , surgery , biology , genetics , lactation
Objective To evaluate the efficacy of two clinical methods of post‐embryo transfer protocols in patients undergoing in vitro fertilisation. Design Prospective, randomised clinical trial. Setting Hospital‐based clinic for reproductive medicine. Sample Women under 40 years of age who were undergoing in vitro fertilisation with GnRH pituitary down‐regulation and controlled ovarian hyperstimulation. Methods Patients were randomised to rest for either 1 or 24 hours after embryo transfer. Main outcome measure Clinical pregnancy per cycle rate (the percentage of cycles started that demonstrated a live fetus on ultrasound examination performed at six or seven weeks of gestation). Results The clinical pregnancy rates were 21.5% for the 1‐hour and 18.2% for the 24‐hour post‐embryo transfer groups. The implantation rate per embryo was significantly higher in the 1‐hour group (14.4%) than in the 24‐hour group (9%). Conclusion One‐hour and 24‐hour rest post‐embryo transfer result in comparable rates of clinical pregnancy. However, 24‐hour rest results in reduced implantation rate per embryo.