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Interaction between hormone replacement therapy preparations and oral anticoagulant therapy
Author(s) -
McLintock L.A.,
Dykes A.,
Tait R.C.,
Walker I.D.
Publication year - 2003
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2003.02035.x
Subject(s) - tibolone , medicine , hormone replacement therapy (female to male) , anticoagulant therapy , oral anticoagulant , anticoagulant , hormone replacement , hormone , warfarin , menopause , atrial fibrillation , testosterone (patch)
There is limited information regarding the interaction of hormone replacement therapy (HRT) and oral anticoagulants. Following the acute over‐anticoagulation of two women shortly after the initiation of tibolone, we have undertaken a retrospective review of anticoagulated women to determine if the dose of oral anticoagulants and quality of anticoagulant control are affected by the introduction of HRT. We demonstrate that acute over‐anticoagulation consistently occurs following the commencement of tibolone and requires anticoagulant dose modification to re‐establish target international normalised ratio (INR). In contrast, non‐tibolone HRT preparations do not consistently alter anticoagulant control or dose requirements.