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The association between maternal HIV‐1 infection and pregnancy outcomes in Dar es Salaam, Tanzania
Author(s) -
Coley Jenny L.,
Msamanga Gernard I.,
Fawzi Mary C. Smith,
Kaaya Sylvia,
Hertzmark Ellen,
Kapiga Saidi,
Spiegelman Donna,
Hunter David,
Fawzi Wafaie W.
Publication year - 2001
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2003.00269.x
Subject(s) - medicine , pregnancy , obstetrics , prospective cohort study , cohort study , cohort , gestation , tanzania , asymptomatic , confounding , genetics , environmental science , environmental planning , biology
Objective To examine the association between maternal HIV infection and pregnancy outcomes controlling for potential confounding factors among a cohort of HIV‐uninfected and HIV‐infected pregnant women in Dar es Salaam, Tanzania. Design Prospective cohort study. Methods A cohort of 1078 HIV‐infected and 502 HIV‐uninfected pregnant women between 12 and 27 weeks of gestation were enrolled and followed up until delivery. Multiple regression models were used to compare the risk of adverse pregnancy outcomes among HIV‐uninfected women with those among HIV‐infected women overall, and separately among asymptomatic or symptomatic HIV‐infected women. Results No significant differences between HIV‐uninfected women and HIV‐infected women were observed in risks of fetal loss or low birthweight or in the weight, head circumference and gestational age of infants at birth. HIV‐infected women were more likely to have severe immature infants (<34 weeks) than HIV‐uninfected women (multivariate RR 1.54 [95% CI 0.90–2.48]; P =0.05). There was a significantly higher risk of low birthweight (RR 2.29, 95% CI 1.34–3.92; P =0.03) and prematurity (<37 weeks) (RR 1.93, 95% CI 1.35–2.77; P =0.0003) among symptomatic HIV‐infected women when compared with HIV‐uninfected women. Conclusion HIV‐infected women, particularly those who are symptomatic, are at a higher risk of adverse pregnancy outcomes.