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Rescue of trophoblast apoptosis by parathyroid hormone‐related protein
Author(s) -
Crocker Ian,
Kaur Malveen,
Hosking David J.,
Baker Philip N.
Publication year - 2002
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2002.01033.x
Subject(s) - staurosporine , parathyroid hormone , apoptosis , parathyroid hormone related protein , medicine , endocrinology , protein kinase a , hormone , biology , chemistry , kinase , calcium , microbiology and biotechnology , biochemistry
The effects of the 1–34 N‐terminal parathyroid hormone‐related protein fragment (0–10μM) and the 67–86 parathyroid hormone‐related protein fragment (0–10μM) on trophoblast apoptosis, induced by TNFα and IFNγ or by the protein kinase inhibitor staurosporine, were investigated. TNFα/IFNγ and staurosporine significantly increased the rate of apoptosis by fivefold and by eightfold, respectively. Parathyroid hormone‐related protein (1–34) evoked a dose‐dependent rescue of both TNFα/IFNγ‐induced and staurosporine‐induced apoptosis, whereas parathyroid hormone‐related protein (67–86) had no significant effect on staurosporine‐induced apoptosis, and only significantly diminished TNFα/IFNγ‐induced apoptosis at 10μM. Parathyroid hormone‐related protein was thus found to be a cytotrophoblast apoptosis survival factor.