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Is there an increased maternal–infant prevalence of Factor V Leiden in association with severe pre‐eclampsia?
Author(s) -
Currie Lea,
Peek Michael,
McNiven Michelle,
Prosser Ian,
Mansour Julia,
Ridgway Jennifer
Publication year - 2002
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2002.00373.x
Subject(s) - medicine , obstetrics , factor v leiden , eclampsia , pregnancy , risk factor , prospective cohort study , pediatrics , thrombosis , genetics , biology , venous thrombosis
Objective To compare the prevalence of the Factor V Leiden mutation in children and maternal–infant pairs in pregnancies affected by severe pre‐eclampsia with unmatched normal controls. Design Prospective cohort study. Setting Department of Women's and Children's Health, The Canberra Hospital, Garran, ACT, Australia. Sample Forty‐eight maternal–infant pairs where the index pregnancy was affected by severe pre‐eclampsia; 46 unmatched maternal–infant pairs where the index pregnancy was defined as normal. Methods DNA analysis of cheek swab samples obtained from maternal–infant pairs for the Factor V Leiden mutation. Main outcome measure The prevalence of the Factor V Leiden mutation in mothers, infants and maternal–infant pairs in association with severe pre‐eclampsia compared with unmatched controls. Results No difference was detected in the prevalence of Factor V Leiden mutation between the women and children of both groups, nor the maternal–infant pairs from each group. Conclusions No evidence was found of an increased prevalence of the Factor V Leiden mutation in either the mothers or children in association with severe pre‐eclampsia. This result argues against a Factor V Leiden fetal or maternal contribution to the development of severe pre‐eclampsia.