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Maternal endothelial soluble cell adhesion molecules with isolated small for gestational age fetuses: comparison with pre‐eclampsia
Author(s) -
Bretelle Florence,
Sabatier Florence,
Blann Andrew,
D'Ercole Claude,
Boutière Brigitte,
Mutin Muriel,
Boubli Léon,
Sampol José,
DignatGeorge Franc¸oise
Publication year - 2001
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2001.00259.x
Subject(s) - cell adhesion molecule , fetus , gestational age , e selectin , soluble cell adhesion molecules , intercellular adhesion molecule 1 , adhesion , cell adhesion , eclampsia , intercellular adhesion molecule , medicine , andrology , endothelial stem cell , endocrinology , chemistry , pregnancy , immunology , biology , biochemistry , in vitro , genetics , organic chemistry
Objective 1.To evaluate the activation profile of the endothelium in pregnancies complicated by small for gestational age fetuses compared with pre‐eclampsia and normal pregnancy, by measuring the plasma levels of soluble adhesion molecules soluble E‐selectin, intercellular cell adhesion molecule‐1 and vascular cell adhesion molecule‐1. 2. To determine whether soluble adhesion molecules were related to the severity of small for gestational age fetuses and pre‐eclampsia. Design Observational study. Participants Sixteen women with small for gestational age fetuses; 15 women with pre‐eclampsia and 15 healthy primigravidae were recruited as controls. Methods Plasma levels of soluble E‐selectin, intercellular cell adhesion molecule‐1 and vascular cell adhesion molecule‐1 were measured by ELISA. Results Compared with the healthy controls, soluble E‐selectin was significantly increased in both small for gestational age fetuses and pre‐eclampsia, whereas intercellular cell adhesion molecule‐1 and vascular cell adhesion molecule‐1 were increased only in pre‐eclampsia. In the small for gestational age fetuses group, soluble E‐selectin correlated inversely with the ratio between birthweight and the expected normal birthweight (r=‐0.4, P =0.007). In the pre‐eclampsia group, a significant correlation was observed between vascular cell adhesion molecule‐1 and blood pressure (r=0.54, P =0.039). Conclusions Endothelial activation, reflected by raised levels of soluble E‐selectin, is a feature of small for gestational age fetuses and is correlated with the severity of the disease. Differences in the profile of soluble cell adhesion molecules suggest variations in the degrees of endothelial activation between pre‐eclampsia and small for gestational age fetuses.