Premium
Maternal thyroid disease: a risk factor for newborn encephalopathy in term infants
Author(s) -
Badawi Nadia,
Kurinczuk Jennifer J.,
Mackenzie Claire L.,
Keogh John M.,
Burton Paul R.,
Pemberton Patrick J.,
Stanley Fiona J.
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb13344.x
Subject(s) - medicine , pregnancy , encephalopathy , thyroid function , thyroid , thyroid disease , disease , pediatrics , risk factor , obstetrics , endocrinology , genetics , biology
Two previously published studies of term newborn encephalopathy showed that maternal thyroid disease to be a risk factor. From these studies we identified 13 case and three control mothers with thyroid disease and investigated them further. The majority of affected case mothers had idiopathic or autoimmune hypothyroidism. Compared with control mothers, case mothers had fewer thyroid function tests in pregnancy, were more likely to remain on the same dose of medication throughout pregnancy and to have experienced other pregnancy complications. The association between maternal thyroid disease and encephalopathy may be the result of a series of different causal pathways, some of which are suggested by our data.