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A comparison of the side effects of prilocaine with felypressin and lignocaine with adrenaline in large loop excision of the transformation zone of the cervix: results of a randomised trial
Author(s) -
Howells R. E. J.,
Tucker H.,
Millinship J.,
Shroff J. Foden,
Dhar K. K.,
Jones P. W.,
Redman C. W. E.
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb11575.x
Subject(s) - medicine , prilocaine , anesthesia , cervix , levobupivacaine , local anaesthetic , surgery , side effect (computer science) , randomized controlled trial , blood loss , visual analogue scale , local anesthetic , bupivacaine , cancer , computer science , programming language
Objective To test the hypothesis that prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline when performing large loop excision of the transformation zone of the cervix. Design Randomised trial. Setting Colposcopy clinic in a large district general hospital. Participants Two hundred consecutive women undergoing large loop excision of the transformation zone of the cervix. Methods Two different local anaesthetic combinations (prilocaine with felypressin and lignocaine with adrenaline) were compared in women undergoing large loop excision of the transformation zone. Prospective collection of clinical and treatment data was undertaken with scoring using an ordinal scale of pain experienced by the women during the procedure. Peri‐operative blood loss and any side effects were also recorded. Main outcome measures Side effects associated with the local anaesthetic agents. Results Lignocaine with adrenaline resulted in less blood loss ( P = 0.006 ) but was more likely to cause side effects, such as feeling faint ( P = 0.017 ) and shaking ( P < 0.001 ). Conclusion Prilocaine with felypressin causes fewer side effects than lignocaine with adrenaline and is therefore the preferred local anaesthetic combination for large loop excision of the transformation zone.