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Site of origin of epithelial ovarian cancer: the endometriosis connection
Author(s) -
Vercellini Paolo,
Scarfone Giovanna,
Bolis Giorgio,
Stellato Giovanna,
Carinelli Silvestro,
Crosignani Pier Giorgio
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb11116.x
Subject(s) - serous fluid , endometriosis , medicine , clear cell , stage (stratigraphy) , clear cell carcinoma , ovarian cancer , pathology , cancer , carcinoma , biology , paleontology
To investigate the left‐ and right‐sided distribution of ovarian malignant surface epithelial tumours, data were collected on 209 women undergoing first‐line surgery for Stage I and II disease. Considering the unilateral cancers, the observed proportion of left‐sided lesions was 35/54 (65%) in the endometrioid, 20/45 (44%) in the serous, 19/35 (54%) in the clear cell, 13/29 (45%) in the mucinous, 2/8 (25%) in the mixed, and 2/5 (40%) in the undifferentiated histological type group. The proportion of left‐sided unilateral endometrioid cancers was significantly different from the expected 50% (χ 2 1 , 4.74, P = 0.03 ) and very similar to that previously observed for benign endometriotic cysts, constituting further evidence in favour of a possible development of endometrioid cancers from the latter lesions.