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Elevated circulating homocyst(e)ine levels in placental vascular disease and associated pre‐eclampsia
Author(s) -
Wang Jian,
Trudinger Brian J.,
Duarte Natalia,
Wilcken David E.,
Li Wang Xing
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb11095.x
Subject(s) - eclampsia , fetus , fetal circulation , medicine , placenta , vascular disease , endocrinology , pregnancy , preeclampsia , atherosclerotic vascular disease , biology , genetics
We examined the hypothesis that hyperhomocyst(e)inaemia in the maternal or fetal circulation is associated with placental vascular disease with either the maternal syndrome of pre‐eclampsia and/or fetal syndrome of growth restriction. Maternal plasma homocyst(e)ine levels were significantly higher in pregnancies complicated by pre‐eclampsia, pregnancies with evidence of umbilical placental vascular disease, and pregnancies with both complications compared with the normal pregnancy group. In the fetal circulation mean plasma homocyst(e)ine concentration was significantly higher in the pre‐eclampsia group compared with the normal group. The results suggest that hyperhomocyst(e)inaemia may be a risk marker for placental vascular disease and maternal pre‐eclampsia. The elevated fetal plasma homocyst(e)ine concentrations, found only in the group of pregnancies with pre‐eclampsia in the absence of umbilical placental vascular disease, may be due to an effect of placental vascular disease on homocyst(e)ine transfer from the maternal to fetal circulation.