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Determinants of umbilical cord arterial 8‐iso‐prostaglandin F 2α concentrations
Author(s) -
Qin Yun,
Wang Chi Chiu,
Kuhn Hartmut,
Rathmann Jorg,
Pang Chi Pui,
Rogers Michael Scott
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb10399.x
Subject(s) - umbilical cord , cord blood , arterial blood , venous blood , fetus , medicine , oxidative stress , cord , base excess , fetal distress , malondialdehyde , anesthesia , surgery , pregnancy , biology , anatomy , genetics
Objective To determine the concentration of 8‐isoPGF 2α in cord blood as a measure of oxidative stress during labour, and to compare them with other established parameters of in vivo lipid peroxidation and with the acid‐base status of the newborn. Method Umbilical cord arterial and venous blood samples were collected from 81 singleton term deliveries for determination of 8‐isoPGF 2α , malondialdehyde and organic hydroperoxides. In addition, metabolites derived from the oxidative metabolism of purines during hypoxia‐reoxygenation and routine cord blood of oxygen saturation, pH, pO 2 , pCO 2 , HCO 3 and base excess were measured. Results Arterial concentrations of 8‐isoPGF 2α were significantly higher in cases with fetal distress, tight nuchal cord ( P < 0.001 ), the umbilical coiling index, and male sex ( P < 0.05 ) (R 2 = 0.48). No correlation was found with any parameter of acid‐base status. In arterial and venous blood the concentrations of organic hydroperoxides and hypoxanthine significantly correlated with the fetal nuchal cord ( P < 0.001 ) (R 2 = 0.26 and 0.16, respectively). Conclusion Our findings indicate that 8‐isoPGF 2α in cord arterial blood is a suitable parameter to quantify a possible oxidative stress in the fetus during labour. Measurements of the F 2 ‐isoprostane concentrations in cord blood at labour provide a clinically useful method to assess the perinatal outcome.