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Pregnancy outcome in carriers of fragile X
Author(s) -
Kallinen Juuso,
Korhonen Kati,
Kortelainen Saara,
Hein Seppo,
Ryynänen Markku
Publication year - 2000
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.2000.tb10398.x
Subject(s) - pregnancy , medicine , obstetrics and gynaecology , obstetrics , logistic regression , outcome (game theory) , singleton , population , university hospital , gynecology , pediatrics , family medicine , biology , genetics , mathematics , environmental health , mathematical economics
Objective To evaluate pregnancy outcome in women who are carriers of fragile X. Design Cross‐sectional case‐control study. Setting Department of Obstetrics and Gynaecology, Kuopio University Hospital, Finland. Sample Sixty‐three singleton pregnancies in carriers of fragile X who were referred for genetic counselling and prenatal diagnosis to Kuopio University Hospital. Methods Logistic regression analysis was used to compare pregnancy outcome in women who are fragile X carrier with outcome of the general obstetric population. Results Carriers of fragile X often experienced more bleeding in late pregnancy than did the reference group. Otherwise, the course and outcome of pregnancy were comparable in both groups. Conclusion Pregnancy outcome in women who are carriers of fragile X is favourable. There is no need to initiate special fetal monitoring because of the fragile X status of the woman.