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5,10 methylenetetrahydrofolate reductase polymorphism in black South African women with pre‐eclampsia
Author(s) -
Chikosi A.B.,
Moodley J.,
Pegoraro R. J.,
Lanning P.A.,
Rom L.
Publication year - 1999
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1999.tb08152.x
Subject(s) - methylenetetrahydrofolate reductase , eclampsia , allele , polymorphism (computer science) , allele frequency , gene polymorphism , medicine , pathogenesis , genetics , pregnancy , gene , biology
The polymorphic C677T mutation in the gene encoding 5,10 methylenetetrahydrofolate reductase has been shown to be a risk factor for pre‐eclampsia in Japanese and European women when inherited as a homozygous trait. We attempted to verify these findings in a black African population with a high incidence of pre‐eclampsia. No difference in frequency of the T‐allele was observed in 105 women with pre‐eclampsia, compared with 110 healthy pregnant normotensive women. Only one woman with pre‐eclampsia was TT homozygous, suggesting that methylenetetrahydrofolate reductase polymorphism is not an important factor in the pathogenesis of pre‐eclampsia in black South African women.