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Expression of endothelin‐1 in amniotic fluid embolism and possible pathophysiological mechanism
Author(s) -
Khong T. Y.
Publication year - 1998
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1998.tb10214.x
Subject(s) - amniotic fluid , endothelin 1 , amniotic fluid embolism , pathology , endothelin receptor , medicine , endothelium , lung , pathophysiology , hemodynamics , epithelium , respiratory epithelium , endocrinology , biology , fetus , receptor , pregnancy , genetics
Since endothelin is a potent vasoconstrictor and bronchoconstrictor, endothelin‐1 expression in the lung was investigated using immunohistological techniques in two cases of amniotic fluid embolism. Intense expression of endothelin‐1 was observed in amniotic squames while weaker staining was seen in alveolar epithelium, bronchiolar epithelium and intraalveolar macrophages and focally in vascular endothelium. Endothelin‐1 may play a role in the early and transient haemodynamic alteration of pulmonary hypertension in amniotic fluid embolism.