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A randomised placebo‐controlled trial of ursodeoxycholic acid and S‐adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy
Author(s) -
Nicastri P. L.,
Diaferia A.,
Tartagni M.,
Loizzi P.,
Fanelli M.
Publication year - 1998
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1998.tb09976.x
Subject(s) - ursodeoxycholic acid , placebo , itching , medicine , cholestasis of pregnancy , gastroenterology , cholestasis , bile acid , pregnancy , population , liver function , surgery , fetus , pathology , biology , alternative medicine , environmental health , genetics
A randomised placebo controlled study was performed in 32 women with intrdhepatic cholestasis of pregnancy. The population was divided into four groups: for 20 days each group was treated only with ursodeoxycholic acid, or S‐adenosylmethionine, or a combination of both drugs, or a placebo (vitamin). Itching, standard liver function tests and serum total bile acids were measured before, during, and after treatment. Itching improved in all the women as well as the biochemical abnormalities. No side‐effects in the mother or in the infant were recorded during and after therapy. A combination of ursodeoxycholic acid and S‐adenosylmethionine is more effective than placebo and than either drug alone.