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Glycosylated haemoglobin and hypertension arising in pregnancy
Author(s) -
Roberts R. N.,
Traub A. I.,
Kennedy A. L.,
Hadden D. R.
Publication year - 1998
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1998.tb09947.x
Subject(s) - gestational hypertension , medicine , gestation , eclampsia , pregnancy , body mass index , gestational age , obstetrics , insulin resistance , endocrinology , insulin , genetics , biology
We analysed a database of glycosylated haemoglobin (HbA1) in nondiabetic pregnant women to investigate the relation between glucose metabolism in the first and second trimesters and hypertensive complications of pregnancy. From a total of 1334 women, 13 had pre‐existing hypertension, 225 developed gestational hypertension and 51 developed pre‐eclampsia. At 28 weeks of gestation, the women who susequently developed gestational hypertension had a significantly higher mean HbAl than those who remained normotensive (6.33 vs 6.17%, P < 0.02 ). This difference remained significant after correcting for the effects of age and body mass index (regression coefficient 0.11, SE 0.06, P = 0.05). In contrast, there were no significant differences in HbAl between the women with pre‐eclampsia and their normotensive counterparts. This provides indirect evidence to support our hypothesis that gestational hypertension is associated with insulin resistance but pre‐eclampsia is not.