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Serum concentrations of cancer antigen 125, placental alkaline phosphatase, cancer‐associated serum antigen and free beta human chorionic gonadotrophin as prognostic markers for epithelial ovarian cancer
Author(s) -
Ind Thomas,
Iles Ray,
Shepherd John,
Chard Tim
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb12061.x
Subject(s) - cancer antigen , placental alkaline phosphatase , alkaline phosphatase , cancer , antigen , ovarian cancer , epithelial ovarian cancer , medicine , endocrinology , cancer research , biology , immunology , enzyme , biochemistry
Objective To investigate the prognostic significance of elevated levels of cancer antigen 125 (CA125), placental alkaline phosphatase (PLAP), free β human chorionic gonadotrophin (hCG) and cancer‐associated serum antigen (CASA) in women with primary epithelial ovarian carcinoma. Design A two year follow up study of survival. Setting A tertiary care gynaecological oncology unit. Participants One hundred and eleven women with histologically confirmed epithelial ovarian cancer. Main outcome measures Survival over a two year period. Results Stage corrected log‐rank χ 2 tests demonstrated a significant effect on survival for all four tumour markers (CA125 P = 0.0142 ; PLAP P < 0.0001 ; CASA P = 0.0098 ; hCG P = 0.0002 ). This was confirmed when each variable was fitted together with disease stage in Cox proportional hazard models. When fitted as multiple variables in a Cox proportional hazard model, the addition of free β‐ hCG and CASA to disease stage, PLAP concentrations and CA125 levels did not demonstrate further prognostic value. Conclusions Levels of all four markers correlate with survival in patients with epithelial ovarian cancer. The combination of PLAP and CA125 concentrations together with disease stage may be used to predict survival but the addition of hCG and CASA levels do not give additional prognostic information.