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Maternal serum alpha‐fetoprotein in fetal neural tube and abdominal wall defects at 10 to 14 weeks of gestation
Author(s) -
Sebire N. J.,
Spencer K.,
Noble P. L.,
Hughes K.,
Nicolaides K. H.
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb12034.x
Subject(s) - neural tube , gestation , fetus , abdominal wall , obstetrics , alpha (finance) , tube (container) , medicine , alpha fetoprotein , pregnancy , anatomy , biology , materials science , surgery , embryo , microbiology and biotechnology , construct validity , genetics , hepatocellular carcinoma , patient satisfaction , composite material
Maternal serum alpha‐fetoprotein concentration was determined in nine pregnancies with fetal anencephaly, seven with exomphalos containing liver, two with spina bifida and 100 normal controls at 10 to 14 weeks of gestation. The median alpha‐fetoprotein in the group with fetal anencephaly and exomphalos was significantly higher than in normal fetuses but the sensitivity of this test is likely to be only about 30% for a false positive rate of 5%.