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Indicators of platelet turnover in thrombocytopenic infants
Author(s) -
Sciscione Anthony C.,
Bessos Hagop,
Callan Nancy,
Blakemore Karin,
Kickler Thomas
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb11990.x
Subject(s) - thrombopoiesis , medicine , platelet , cord blood , pathophysiology , endocrinology , gastroenterology , immunology , cardiology , biology , genetics , stem cell , haematopoiesis , megakaryocyte
Glycocalicin has been found to be a marker of increased platelet turnover, while interleukin‐6 may be increased in response to thrombocytopenia. We used these markers to study the pathophysiology of thrombocytopenia in newborn infants. Cord blood platelet counts were obtained from 499 infants. Thrombocytopenic infants (< 100,000/mm 3 ) and a control group had ELISA assays for interleukin‐6 and glycocalicin performed. The mean levels of glycocalicin and interleukin‐6 were elevated in cord blood of thrombocytopaenic infants. Infants with intrauterine growth restriction and thrombocytopaenia had no detectable glycocalicin in their plasma, despite elevated levels of interleukin‐6. This probably reflects impaired thrombopoiesis in these infants.