Premium
Ploidy profile of morphologically normal squamous epithelium adjacent to high grade cervical intraepithelial neoplasia
Author(s) -
McDermott N.,
Suliman Y.,
Walsh C. Barry,
Kay E. W.,
Curran B.,
Milburn C.,
Turner M.,
Prendiville W.,
Leader M.
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb11545.x
Subject(s) - ploidy , pathology , flow cytometry , biology , cervical intraepithelial neoplasia , epithelium , cervix , microbiology and biotechnology , medicine , cervical cancer , cancer , genetics , gene
We have investigated the ploidy profile of morphologically normal mucosa adjacent to high grade CIN ( n = 16 ) and also from normal cervix ( n = 18). DNA ploidy was assessed using flow cytometry and image analysis. All cases were diploid by both modalities. Our results show that morphologically normal squamous mucosa has a stable ploidy profile even when it lies adjacent to high grade CIN. This finding supports the view that high grade CIN is a neoplastic expansion of transformed cells rather than the result of a field change effect.