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Interleukin‐8 in urine: a new diagnostic parameter for intra‐amniotic infection after premature rupture of the membranes
Author(s) -
Stiemer Beate,
Buschmann Anke,
Bisson Susanne,
Hensel Karin,
Gramm HansJoachim,
Hopp Hartmut,
Weitzel HansKarl
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb11504.x
Subject(s) - amnion , urine , amniotic fluid , premature rupture of membranes , decidua , pregnancy , urinary system , medicine , obstetrics , fetus , interleukin 6 , andrology , biology , inflammation , placenta , genetics
Interleukin‐8 (IL‐8), a 72 amino acid peptide secreted by cells of the immune system and of the amnion, chorion and decidua, was measured in women in late pregnancy. IL‐8 was detected in the urine of 91 of 104 women with premature rupture of the fetal membranes, with values exceeding 1000 ng/L in cases of severe intra‐amniotic infection. Women with urinary tract infections were excluded. The routine measurement of IL‐8 in urine, together with C‐reactive protein in serum, thus provides a low risk and technically simple approach to the assessment of intra‐amniotic infection.