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Bradykinin stimulates interleukin‐6 and interleukin‐8 secretion of human decidua derived cells
Author(s) -
Rehbock J.,
Chondromatidou A.,
Buchinger P.,
Hermann A.,
Jochum M.
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb11503.x
Subject(s) - bradykinin , decidua , secretion , paracrine signalling , endocrinology , cytokine , medicine , interleukin , chemistry , biology , fetus , receptor , pregnancy , placenta , genetics
Cytokines are known to participate in the process of parturition within a paracrine network in fetal membranes. Bradykinin can also contribute to this process, increasing the release of eicosanoids from decidua cells. In this study, we present evidence for a cross‐link between bradykinin and the cytokines. Short and long term cultures of human decidua cells were incubated for 4 h and 24 h with and without bradykinin. IL‐6 and IL‐8 were determined in the supernatants by ELISA. Results show a large intermdividual variability in the basal secretion of IL‐6 and IL‐8 and a clear increase in the secretion of both ILs in response to bradykinin. By this amplifying effect on cytokine secretion, bradykinin can initiate local and systemic effects of amniochorionitis.