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Elevation of serum interleukin‐1 receptor antagonist levels in women with gynaecological cancers
Author(s) -
Fujiwaki Ritsuto,
Hata Toshiyuki,
Miyazaki Kohji,
Kawamura Takae,
Inada Katsuya
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb11012.x
Subject(s) - medicine , gynaecological cancer , endometrial cancer , interleukin 1 receptor antagonist , ovarian cancer , cancer , gynecology , epithelial ovarian cancer , cervical cancer , oncology , antagonist , receptor antagonist , receptor
This study included 15 patients with gynaecological cancers (7 with cervical cancer, 6 with endometrial cancer, and 12 with ovarian cancer); 7 with benign gynaecological disorders (5 with benign ovarian tumour and 2 with uterine myoma); and 10 healthy women as a control group. Serum interleukin‐1 receptor antagonist (IL‐1 ra) levels in patients with gynaecological cancer were significantly higher than those in patients with benign gynaecological disorders (P = 0.04) and in healthy controls (P = 0.0009). IL‐1 ra may play an important role in host immune responses in local and general environments against gynaecological cancers.