Premium
HLA‐G polymorphism in Finnish couples with recurrent spontaneous miscarriage
Author(s) -
Karhukorpi Jari,
Laitinen Tarja,
Tiilikainen Anja S.
Publication year - 1997
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1997.tb10951.x
Subject(s) - human leukocyte antigen , hla g , allele , haplotype , locus (genetics) , recurrent miscarriage , histocompatibility , genetics , immunology , miscarriage , major histocompatibility complex , pregnancy , biology , gene , antigen
HLA‐G is a class 1 major histocompatibility complex gene that is expressed in cytotrophoblasts at the materno‐fetal interface. It has been suggested that HLA‐G could play a key role in materno‐fetal immunological interactions during pregnancy. To investigate whether there is an association between HLA‐G locus and recurrent spontaneous miscarriage, HLA‐G alleles were determined by a PCR‐RFLP method in 38 couples with recurrent spontaneous miscarriage and in 26 random control couples. In this series parental HLA‐G sharing, extended HLA‐G/A haplotypes and the frequencies of the HLA‐G alleles were similar in the two groups. Thus, our data suggest that there is no detectable relation between susceptibility to recurrent spontaneous miscarriage and HLA‐G locus.