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Wedge resection to improve insulin resistance in polycystic ovary syndrome: a study among Chinese women
Author(s) -
Wu Xiaoke,
Su Yanhua,
Zhang Zuxuan
Publication year - 1996
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1996.tb09881.x
Subject(s) - polycystic ovary , insulin resistance , medicine , endocrinology , insulin , c peptide , androgen , glucose tolerance test , body mass index , hormone
Objective To investigate the relation between androgen excess and insulin resistance in nonobese Chinese women with polycystic ovary syndrome. Design A prospective, controlled study. Setting School of Clinical Medicine, Nanjing University. Subjects There were three groups: Group 1 ( n = 15 ) comprised nonobese women with polycystic ovary syndrome; Group 2 comprised 12 of these 15 women in whom bilateral wedge resection had been performed six months to one year before enrolling in the study. Group 3 was a control group comprised of 15 normally menstruating women of similar age and body mass index. Methods An oral glucose (100 g) tolerance test was performed in all women in each group. The areas under the response curve of serum glucose, insulin, C‐peptide (C‐P), insulin/glucose (I/G) and C‐P/insulin (C/I) were calculated by trapezoid rule. Results When fasting the three groups had similar levels of glucose, insulin, C‐P, I/G and C/I. During the oral glucose tolerance test women of Group 1 had a significantly higher mean serum area of the curve of glucose, insulin, C‐P and I/G levels and lower C/I values, compared with the other two groups. Women of Group 2 and those in the control group showed similar levels of these indices during the oral glucose tolerance test. Conclusions Androgen excess in women with polycystic ovary syndrome may be responsible for a defect in peripheral insulin sensitivity and hepatic extraction which could be reversed by removing excessive androgens with wedge resection.