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Fetal size at birth in relation to quality of blood glucose control in pregnancies complicated by pregestational diabetes mellitus
Author(s) -
Persson B.,
Hanson U.
Publication year - 1996
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1996.tb09768.x
Subject(s) - medicine , postprandial , gestation , obstetrics , pregnancy , gestational age , birth weight , diabetes mellitus , gestational diabetes , fetus , endocrinology , biology , genetics
Objective To determine the relation between maternal levels of blood glucose and glycated haemoglobin (HbAlc) and infant size at birth in pregestational diabetes. Design Longitudinal study from 6 to 14 weeks gestation. Women were treated intensively with insulin, aiming at normoglycaemia but avoiding hypoglycaemia. Blood glucose was determined six times daily, HbAlc every four weeks. Individual mean fasting and postprandial glucose levels were calculated for three‐week periods of gestation. Birthweight > 2 SD or within ±2 SD for gestational age and gender was classified as large (LGA) or appropriate (AGA), respectively. Birthweight ratio was calculated as the ratio of birthweight to normal mean birthweight after correction for gestational age and gender. Participants One hundred and thirteen consecutive pregnant women with pregestational diabetes and their newborn infants. Results Perinatal mortality was nil, the rates of spontaneous preterm delivery (8.9 %) and severe maternal hypoglycaemia (4.4 %) were low. Mothers with LGA infants (26 %) had a significantly higher fasting glucose between weeks 27 and 32 than mothers of AGA infants ( P < 0.01 ). Relative birthweight was significantly and independently associated with pre‐pregnancy bodyweight ( r = 0.24, P 005 ) and fasting glucose at weeks 27 to 29 ( r = 0.27, P 0.01 ) but together could only explain 12.3 % of the variation in birthweight (mult. r = 0.35, P 0.01 ). HbAlc correlated with glucose levels but was unrelated to birthweight ratio. The fasting glucose level between weeks 30 and 32 was significantly interrelated with the fasting glucose level from each of the six preceding three‐week periods. Conclusion Near normoglycaemia cannot be obtained in all patients, presumably due to intrinsic differences in glucoregulatory ability between individuals. The incidence of LGA infants was unexpectedly high. The modest abnormality in glycaemic control in mothers with LGA infants could only partly explain fetal oversize, suggesting that other factors must be implicated to explain fetal growth acceleration.