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Hormone replacement therapy, sleep quality and psychological wellbeing
Author(s) -
Purdie David W.,
Empson Jacob A. C.,
Crichton Caroline,
Macdonald Linda
Publication year - 1995
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1995.tb11433.x
Subject(s) - hormone replacement therapy (female to male) , pittsburgh sleep quality index , vasomotor , physical therapy , medicine , sleep onset , menopause , psychology , sleep quality , cognition , psychiatry , insomnia , testosterone (patch)
Objective To examine the effect of hormone replacement therapy upon sleep quality and duration in postmenopausal women. Design Randomised, single‐blind, placebo‐controlled trial. Setting Sleep research laboratory. Subjects Thirty‐three healthy postmenopausal women. Interventions Continuous 0–625 mg conjugated equine oestrogens with 0.15 mg cyclic norgestrel taken for 12 days per 28 day cycle. Main outcome measures Occurrence of vasomotor symptoms, polysomnographic sleep stage measures, Stanford sleepiness questionnaire, Crown‐Crisp experiential index and the cognitive failures questionnaire. Results Hormone replacement therapy results in an improvement in menopausal symptoms but not in parameters of sleep quality. Despite this, certain measures of psychological wellbeing showed significant improvement in the hormone replacement therapy group. Conclusion Hormone replacement therapy results in a measurable improvement in physical and psychological welfare, the latter being independent of improvement in sleep quality.