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First trimester fetal nuchal translucency: Problems with screening the general population 2.
Author(s) -
Bewley S.,
Roberts L. J.,
Mackinson AM.,
Rodeck C. H.
Publication year - 1995
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1995.tb11290.x
Subject(s) - nuchal translucency , obstetrics , first trimester , nuchal translucency measurement , medicine , population , fetus , pregnancy , biology , environmental health , genetics
Objective To investigate first trimester nuchal translucency 3 mm as a screening test for aneuploidy in the normal pregnant population. Design A pilot observational study. Setting University College Hospital, London. Subjects One thousand one hundred and twenty‐seven women had measurements of nuchal translucency at the time of their dating scan (8–13 weeks of gestation). Results Seventy fetuses (6%) had a nuchal translucency ≥ 3 mm. Five karyotypically abnormal fetuses were identified by standard routine techniques (three trisomy 21, two trisomy 18), all in high risk mothers (239 years). Only two had nuchal translucency ≥ 3 mm (one trisomy 21, one trisomy 18). Conclusions Although nuchal translucency measurement is feasible and promising, there is at present insufficient data to warrant its introduction for screening of the general population, or to replace traditional second trimester screening.