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Human papillomavirus vulvitis: a new disease or an unfortunate mistake?
Author(s) -
Dennerstein Graeme J.,
Scurry James P.,
Garland Suzanne M.,
Brenan John A.,
Fortune Denys W.,
Sfameni Salvatore F.,
O'Keefe Rodney J.,
Tabrizi Sepehr N.
Publication year - 1994
Publication title -
bjog: an international journal of obstetrics and gynaecology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.157
H-Index - 164
eISSN - 1471-0528
pISSN - 1470-0328
DOI - 10.1111/j.1471-0528.1994.tb13046.x
Subject(s) - vulvitis , medicine , disease , population , dermatology , vulva , human papillomavirus , hpv infection , vulvodynia , gynecology , pathology , surgery , cervical cancer , pelvic pain , cancer , vaginitis , environmental health
Objective To determine whether human papillomavirus (HPV) was responsible for symptoms in women with vulvar pruritus, pain and superficial dyspareunia who had been referred with a diagnosis of HPV vulvar disease made on clinical and/or colposcopic and/or histological grounds. Design In addition to standard clinical and laboratory investigations of the whole population, a sample of 15 test cases from the population of 71 women referred with a clinicopathological diagnosis of HPV vulvar disease, and two positive and 21 negative controls were assayed for HPV DNA. Polymerase chain reaction assays using L1 consensus primers were performed blinded to the clinicopathological diagnosis. Setting Dermogynaecology Clinic at Mercy Hospital for Women. Subjects Seventy‐one women referred with a diagnosis of HPV vulvar disease. Results Thirteen cases which could be tested for HPV DNA were negative. Diagnoses other than HPV were found for the women's presentation in all cases. Conclusions In the population studied, our investigations indicated that the clinicopathological diagnosis of HPV infection was incorrect and that HPV was not a cause of vulvar symptoms. We believe that the term HPV vulvitis is unfortunate as it has invited destructive treatments and drawn attention away from more likely causes of this difficult group of vulvar conditions.